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目的观察硫酸吗啡缓释片治疗晚期癌性疾病的效果。方法采用美国路坦医药公司的新型硫酸吗啡缓释片（即路泰），应用于中重度癌症患者，用量为10～60mg／次，隔12小时口服1次。结果吗啡缓释片对中度癌性疼痛者，有效率为90．9％（20／22），重度癌痛者为91．6％（22／24），总有效率为91．3％（42／46），常见副作用为恶心、呕吐、嗜睡、头昏、便秘等。结论吗啡缓释片作为晚期癌痛患者止痛治疗，疗效明显，服用方便，安全，无成瘾性及呼吸抑制现象。
Abstract：Objective To observe the therapeutic effectiveness of morphine sulfate controlled release tablets in treating advanced carcinomatous pain. Methods We used novel morphine sulfate modified release tablets produced by American pharma CO. LTD. to treat moderate and severe cancer patients. The dosage was 10-60mg for every 12 hours. Results The effective rate of morphine modified release tablets was 90. 9% (120/22) in treating moderate carcinomatous pain patients,and it was 91. 3 % (42/46) in severe carcinomatous pain patients. The common side effects were nausea,vomiting, lethargy, dizziness and constipation. Conclusion Morphine modified release tablets were analgesic to advanced cancer patients with significant therapeutic effectiveness. It was easy and safe to take,and had no addiction and respiratory inhibition.[
1 李同度.三阶梯癌症疼痛治疗方案推行中的问题.实用肿瘤杂志,1997;12(4):146
2 陈志平,顾鸿刚,张明,等.三阶梯疗法治疗癌症疼痛.实用肿瘤杂志,1997;12(4):158
3 刘秀荣.三阶梯药物治疗晚期癌痛的临床探讨.河南肿瘤学杂志,1998;11(3):235
4 许德明,劳逸,陈国权,等.硫酸吗啡控释片治疗癌痛48例报告.实用癌症杂志,1997;12(1):48
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基本信息:
DOI：10.13455/j.cnki.cjcor.1999.05.050
中图分类号:R730.5
引用信息:
[1]高中度,茅爱武,王月芹,蒋经辉,张丽君.硫酸吗啡缓释片治疗晚期癌症疼痛疗效观察[J].中国肿瘤临床与康复,1999(05).DOI:10.13455/j.cnki.cjcor.1999.05.050.
1999-10-19
1999-10-19