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目的探讨糖类抗原(CA) 125、甲胎蛋白(AFP)、癌胚抗原(CEA)和CA199等相关肿瘤标志物联合检测在食管癌中的诊断价值。方法选取2017年8月至2019年2月间西安市西安交通大学第二附属医院消化内科收治的40例食管良性肿瘤(良性组)和90例食管癌(食管癌组)作为研究对象,检测两组患者血清CA125、AFP、CEA和CA199含量,判断阳性率与诊断价值。结果食管癌组的血清CA125、AFP、CEA和CA199含量均显著高于良性组,差异均有统计学意义(均P <0. 05)。食管癌组的CA125、AFP、CEA和CA199阳性率分别为94. 4%、84. 4%、90. 0%和80. 0%,显著高于良性组的37. 5%、35. 0%、30. 0%和35. 0%,差异均有统计学意义(均P <0. 05)。相关分析显示,CA125、AFP、CEA和CA199阳性率与食管癌存在显著正相关性,差异均有统计学意义(均P <0. 05)。结论 CA125、AFP、CEA和CA199在食管癌中呈高表达状况,与食管癌的发生显著相关,可用来鉴别诊断食管良性肿瘤与食管癌。
Abstract：Objective To investigate the significance of detection of tumor markers including carbohydrate antigen(CA) 125,alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA) and CA199 in the diagnosis of esophageal cancer. Methods From August 2017 to February 2019,40 patients with benign esophageal benign tumors(benign group) and 90 patients with esophageal cancer(esophageal cancer group) who were treated at the Second Affiliated Hospital of Xi'an Jiaotong University were selected as the subjects. The serum CA125,AFP,CEA,CA199 levels were detected and to determine their positive expression rate and diagnostic value. Results The serum levels of CA125,AFP,CEA and CA199 were significantly higher in the esophageal cancer group than in the benign group(all P < 0. 05). The positive rates of CA125,AFP,CEA and CA199 were 94. 4%,84. 4%,90. 0% and 80. 0%,respectively in the esophageal cancer group,which were significantly higher than 37. 5%,35. 0%,30. 0% and 35. 0%,respectively of the benign group(all P < 0. 05). Correlation analysis showed that there were significant positive correlation between the positive expression rates of CA125,AFP,CEA,CA199 and esophageal cancer(all P <0. 05). Conclusion CA125,AFP,CEA and CA199 are highly expressed in esophageal cancer,which is significantly correlated with the incidence of esophageal cancer. They can be used to differentially diagnose benign esophageal and esophageal cancer.
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基本信息:
DOI：10.13455/j.cnki.cjcor.2019.12.19
中图分类号:R735.1
引用信息:
[1]刘巧艳,王进海.相关肿瘤标志物联合检测在食管癌中的诊断价值[J].中国肿瘤临床与康复,2019,26(12):1482-1485.DOI:10.13455/j.cnki.cjcor.2019.12.19.
2019-12-20
2019-12-20