中国肿瘤临床与康复

目的探讨老年人胃癌术后的生存情况及其影响因素。方法回顾性分析收治并行胃癌切除手术的96例患者的临床资料及随访资料。结果胃癌患者术后1、3、5年生存率分别为74.0%、57.3%和19.8%,所有患者的中位生存时间为46.4个月;Log-rank比较分析显示,年龄(2=2.96,P<0.05)、饮酒史(2=9.42,P<0.05)、胃癌转移(2=10.34,P<0.05)、组织学分化程度较高(2=8.83,P<0.05)、浸润程度到达浆膜(2=12.21,P<0.05)等因素对胃癌1、3、5年生存率具有显著影响;Cox回归模型分析显示,饮酒史(RR=1.86,95%CI:1.21².64)、胃癌转移(RR=1.89,95%CI:1.17².55)、组织学分化程度低(RR=2.02,95%CI:1.37².85)、浸润程度到达浆膜(RR=2.18,95%CI:1.29³.01)是影响胃癌术后生存时间的独立因素。结论有饮酒史、术前癌症转移、组织分化程度低、浸润程度较深会影响老年人胃癌术后生存时间。

Objective To study the related factors of prognosis in elderly gastric cancer patients after the operation. Methods The retrospective analysis was used to the study and the information of 96 patients was collected form January 2005 to January 2008. The followed information was also collected. Results The 1-year,3-years,5-years survival rates were 74. 0% 、57. 3% and 19. 8%,and the median survival time was 49. 5 months. The log-rank study found that age( 2= 2. 96,P < 0. 05),drinking history( 2= 9. 42,P < 0. 05),gastric cancer metastasis( 2= 10. 34,P < 0. 05),differentiation( 2= 8. 83,P < 0. 05) and cut-side residues( 2= 12. 21,P < 0. 05) has the significant influence. The results of Cox showed that drinking history( RR = 1. 86,95% CI: 1. 21-2. 64),gastric cancer metastasis( 2= 10. 34,P < 0. 05),differentiation( RR =2. 02,95%CI: 1. 37-2. 85) and cut-side residues( RR =2. 18,95%CI: 1. 29-3. 01) were independently risk factors of the patients' survival time. Conclusions Patient's drinking history,gastric cancer metastasis,differentiation and cut-side residues influence the survival time.